Our aim is to identify rare high-impact variants that play a role in Alzheimer’s disease and other neurodegenerative diseases, in order to increase our understanding of disease etiology and improve clinical diagnosis/prognosis. 

As there are so many rare genetic factors, it is necessary to compare large groups of patients with large groups of healthy individuals. Through this, one can gather enough evidence to establish that a particular hereditary variant leads to an increased risk of getting the disease.

For this purpose, researchers in Europe (EADB/ADES consortium), in the USA (ADSP consortium) and across the world are collaborating. Here, on the Alzheimer Genetics Hub, we bring the data together in a secure environment for analysis.